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This article in NSE

  1. Vol. 37 No. 1, p. 132

    * Corresponding author(s): wdyer@montana.edu
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Herbicide Discovery and Screening

  1. William E. Dyer *
  1. Dyer, Dep. of Plant Sciences and Plant Pathology, Montana State Univ., Bozeman, MT 59717-0312


Historically, herbicides have been discovered by randomly screening collections of chemicals for activity on target weeds. While totally empirical, this approach has been surprisingly successful and has produced essentially all commercial herbicides currently in use. More recently, agrichemical companies have adopted directed strategies using in vitro assays, compound structure/activity relationships, and profiling assays of mRNAs, proteins, and metabolites. These latter approaches, in combination with high-throughput screens, are designed to exploit recent advances in technology as well as our increased understanding of biological systems. At the completion of the lesson, students will be able to:

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